Dr. Rakesh Srivastava

Chemoprevention by resveratrol: molecular mechanisms and therapeutic potential

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Sharmila Shankar, Gyanendra Singh, Rakesh K. Srivastava Department of Biochemistry, University of Texas Health Science Center at Tyler, Tyler, Texas, USA 75703 TABLE OF CONTENTS1. Abstract2. Introduction3. Mechanisms of Action3.1. Regulation of Bcl-2 family members3.2. Regulation of cell cycle3.3. Regulation of MAP kinase3.4. Generation of Reactive Oxygen Species (ROS)3.5. Regulation of PI3-Kinase / AKT Pathway3.6. Regulation […]

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Rakesh Srivastava article

Chronic ethanol exposure of human pancreatic normal ductal epithelial cells induces cancer stem cell phenotype through SATB2

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Wei YuYuming MaSharmila ShankarRakesh K. Srivastava Abstract The incidence of pancreatic cancer is on the rise. Risk factors for pancreatic cancer include alcohol toxicity and metabolic conditions such as obesity, hypertension, dyslipidaemia, insulin resistance and type 2 diabetes. However, the molecular mechanism by which chronic alcohol consumption contributes to pancreatic cancer is not well understood. […]

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