Dr. Rakesh Srivastava

Chemoprevention by resveratrol: molecular mechanisms and therapeutic potential

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Sharmila Shankar, Gyanendra Singh, Rakesh K. Srivastava Department of Biochemistry, University of Texas Health Science Center at Tyler, Tyler, Texas, USA 75703 TABLE OF CONTENTS1. Abstract2. Introduction3. Mechanisms of Action3.1. Regulation of Bcl-2 family members3.2. Regulation of cell cycle3.3. Regulation of MAP kinase3.4. Generation of Reactive Oxygen Species (ROS)3.5. Regulation of PI3-Kinase / AKT Pathway3.6. Regulation […]

Rakesh Srivastava article

Chronic ethanol exposure of human pancreatic normal ductal epithelial cells induces cancer stem cell phenotype through SATB2

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Wei YuYuming MaSharmila ShankarRakesh K. Srivastava Abstract The incidence of pancreatic cancer is on the rise. Risk factors for pancreatic cancer include alcohol toxicity and metabolic conditions such as obesity, hypertension, dyslipidaemia, insulin resistance and type 2 diabetes. However, the molecular mechanism by which chronic alcohol consumption contributes to pancreatic cancer is not well understood. […]

Dr. Rakesh Srivastava article

Research Discovers Potential New Rx Target For Colon Cancer

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SATB2 is a novel “transcription factor” – a protein “switch” that controls which genes are turned on or off inside a cancer cell. Drs. Rakesh Srivastava and Sharmila Shankar identified it in the so-called “cancer stem cells” – cancer cells that behave like stem cells. Cancer stem cells are a small subset of immortal cells in tumors that are […]

Rakesh Srivastava

Volkin, Srivastava Named KU’s Second, Third Eminent Scholars

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Kansas Bioscience Authority Commits $4.3 Million To Support Professors A prominent pharmaceutical scientist with 20 years of industrial research and development experience joined the KU faculty earlier this month, thanks in part to a five-year, $2.5 million financial commitment from the Kansas Bioscience Authority. David Volkin comes to KU from Centocor R&D, a subsidiary of […]